MLN-4760 | ACE2 inhibitor | Probechem Biochemicals

Chemical Structure : MLN-4760

CAS No.: 305335-31-3

加入收藏

MLN-4760 (MLN4760, MLN 4760)

货号: PC-35972Not For Human Use, Lab Use Only.

MLN-4760 (MLN4760) is a potent, selective inhibitor of angiotensin-converting enzyme (ACE)-related carboxypeptidase ACE2 with IC50 of 0.44 nM (hACE2).

规格	价格	库存
5 mg	￥2680	In stock
10 mg	￥4280	In stock
25 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MLN-4760 (MLN4760) is a potent, selective inhibitor of angiotensin-converting enzyme (ACE)-related carboxypeptidase ACE2 with IC50 of 0.44 nM (hACE2).
MLN-4760 displays >5,000-fold selectivity over related enzymes including human testicular ACE (IC50>100 uM) and bovine carboxypeptidase A (IC50=27 uM).
MLN-4760 exacerbated the Ang II-dependent formation of ROS and abolished the generation of Ang-(1-7) from Ang II.
MLN-4760 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats.

物理化学性质&存储条件

分子量	428.31
分子式	C19H23Cl2N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-imidazol4-yl]-ethylamino]-4-methylpentanoic acid

参考文献

1. Towler P, et al. J Biol Chem. 2004 Apr 23;279(17):17996-8007.

2. Dales NA, et al. J Am Chem Soc. 2002 Oct 9;124(40):11852-3.

3. Ye M, et al. Hypertension. 2012 Sep;60(3):730-40.

4. Joshi S, et al. Eur J Pharmacol. 2016 Mar 5;774:25-33.

MLN-4760 (MLN4760, MLN 4760)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MLN-4760 (MLN4760, MLN 4760)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.