MLKL inhibitor P28

Chemical Structure : MLKL inhibitor P28

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货号: PC-21159Not For Human Use, Lab Use Only.

MLKL inhibitor P28 is a potent inhibitor of necroptosis via MLKL inhibition (EC50=10.3 uM), blocks oligomerization and translocation of MLKL.

规格	价格	库存	数量
50 mg		Get quote
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1 g		Get quote

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生物&药学活性

MLKL inhibitor P28 is a potent inhibitor of necroptosis via MLKL inhibition (EC50=10.3 uM), blocks oligomerization and translocation of MLKL.
MLKL inhibitor P28 is more potent than Necrosulfonamide (NSA, Cat#PC-42202) in preventing cell death after exposure to necroptotic stimuli at a concentration of 0.1 μM.
MLKL inhibitor P28 (3 uM) inhibited the expression of α-SMA, collagen-1, CXCL1/CXCL2, MLKL, and ICAM1 in HSC-LX2 cells.
MLKL inhibitor P28 suppressed TSZ-induced cytokine and chemokine production in monocytes.
MLKL inhibitor P28 reduced the expression of ICAM1 and CXCL1/2, which operate via a pathway different from the conventional necroptosis pathway.
Unlike the necrosulfonamide treatment, the P28 treatment did not induce cytotoxicity.

物理化学性质&存储条件

分子量	394.39
分子式	C20H18N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (E)-3-(3-(3-(3-hydroxyphenyl)prop-2-yn-1-yl)-1,7-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)acrylate

参考文献

1. Ju Hee Oh, et al. ACS Pharmacology & Translational Science, 2023.