ML67-33 |CAS:1443290-89-8 Probechem Biochemicals

Chemical Structure : ML67-33

CAS No.: 1443290-89-8

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ML67-33 (ML-67-33;ML 67-33)

货号: PC-60191Not For Human Use, Lab Use Only.

ML67-33 is a low micromolar (EC50=9.7 uM, K2P2.1), selective activator of temperature- and mechano-sensitive K2P potassium channels.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

ML67-33 is a low micromolar (EC50=9.7 uM, K2P2.1), selective activator of temperature- and mechano-sensitive K2P potassium channels.
ML67-33 shows little or no activity against K2P5.1, K2P3.1, K2P9.1, K2P18.1 and Kv7.2 (>100 uM).
ML67-33 reversibly increases channel currents by activating the extracellular selectivity filter-based C-type gate that forms the core gating apparatus on which a variety of diverse modulatory inputs converge.
ML67-33 also is a potent activator of LyPAP and TMEM175-mediated H+ and K+ currents

物理化学性质&存储条件

分子量	374.27
分子式	C18H17Cl2N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,7-Dichloro-9,9-dimethyl-10-[2-(1H-tetrazol-5-yl)-ethyl]-9,10-dihydro-acridine

参考文献

1. Bagriantsev SN, et al. ACS Chem Biol. 2013 Aug 16;8(8):1841-51.

ML67-33 (ML-67-33;ML 67-33)

生物&药学活性

物理化学性质&存储条件

参考文献

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ML67-33 (ML-67-33;ML 67-33)

生物&药学活性

物理化学性质&存储条件

参考文献

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