ML404 | mPTP inhibitor | Probechem Biochemicals

Chemical Structure : ML404

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ML404 (CID72199308, ML 404)

货号: PC-62135Not For Human Use, Lab Use Only.

ML404 is a small molecule inhibitor of mitochondrial permeability transition pore (mtPTP, mPTP), inhibits mitochondrial swelling with EC50 of 4.9 nM, shows no effect on mitochondrial coupling at >100 uM.

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生物&药学活性

ML404 is a small molecule inhibitor of mitochondrial permeability transition pore (mtPTP, mPTP), inhibits mitochondrial swelling with EC50 of 4.9 nM, shows no effect on mitochondrial coupling at >100 uM.
ML404 increases the calcium retention capacity (CRC) of mitochondria (a measure of mtPTP inhibition) 14.8-fold at 12.5 uM, a concentration that does not affect mitochondrial respiration at which the compound appears non-toxic.
ML404 is 2.3-fold more effective inhibitor than GNX-865.

物理化学性质&存储条件

分子量	328.75
分子式	C17H13ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-Chloro-2-methylphenyl)-5-(3-hydroxyphenyl)-3-isoxazolecarboxamide

参考文献

1. Sileikyte J, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

ML404 (CID72199308, ML 404)

生物&药学活性

物理化学性质&存储条件

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ML404 (CID72199308, ML 404)

生物&药学活性

物理化学性质&存储条件

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