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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ML402
ML402

Chemical Structure : ML402

CAS No.: 298684-44-3

ML402 (ML 402;ML-402)

货号: PC-60336Not For Human Use, Lab Use Only.

ML402 is a potent, selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channels activator with EC50 of 13.7 and 5.9 uM, respectively.

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5 mg ¥880 In stock
10 mg ¥1280 In stock
25 mg ¥1980 In stock
50 mg ¥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML402 is a potent, selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channels activator with EC50 of 13.7 and 5.9 uM, respectively.
ML402 displays no significant activity for K2P4.1 (at 50 uM); shows insensitivity to mutant K2P2.1(K271Q), and has similar EC50 for K2P4.1(Q258K) (EC50=13.6 uM).

物理化学性质&存储条件

分子量 295.781
分子式 C14H14ClNO2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide

参考文献

1. Lolicato M, et al. Nature. 2017 Jul 20;547(7663):364-368.

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