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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-ML399
ML399

Chemical Structure : ML399

CAS No.: 1560968-49-1

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ML399 (VU0516340)

货号: PC-62142Not For Human Use, Lab Use Only.

ML399 (VU0516340) is a potent and cell penetrant menin-MLL inhibitor with IC50 of 90 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ML399 (VU0516340) is a potent and cell penetrant menin-MLL inhibitor with IC50 of 90 nM.
    ML399 (VU0516340) shows improved potency and DMPK properties.
    ML399 (VU0516340) is a chemical probe for in vivo proof-of-mechanism studies.

    物理化学性质&存储条件

    分子量 445.538
    分子式 C27H28FN3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-4-(3-(4-((3-Fluorophenyl)(hydroxy)(pyridin-2-yl)methyl)piperidin-1-yl)propoxy)benzonitrile

    参考文献

    1. Senter T, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

    2. Senter T, et al. Bioorg Med Chem Lett. 2015 Jul 1;25(13):2720-5.

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