ML398 |CAS:1620203-88-4 Probechem Biochemicals

Chemical Structure : ML398

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ML398 (CID72737723, ML 398)

货号: PC-62128Not For Human Use, Lab Use Only.

ML398 (CID72737723) is a potent, selective, highly brain penetrant dopamine 4 (D4R) receptor antagonist with IC50/Ki of 130 nM/60 nM.

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生物&药学活性

ML398 (CID72737723) is a potent, selective, highly brain penetrant dopamine 4 (D4R) receptor antagonist with IC50/Ki of 130 nM/60 nM.
ML398 (CID72737723) shows excellent selectivity (>100-fold) against the other dopamine receptor subtypes (D1,2S,2L,3,5; >20 uM).
ML398 (CID72737723) reverses cocaine-induced hyperlocomotion at 10 mg/kg in vivo.

物理化学性质&存储条件

分子量	315.841
分子式	C19H22ClNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(4-chlorobenzyl)-2-phenethylmorpholine

参考文献

1. Berry CB, et al. ACS Med Chem Lett. 2014 Jul 9;5(9):1060-4.

ML398 (CID72737723, ML 398)

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物理化学性质&存储条件

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ML398 (CID72737723, ML 398)

生物&药学活性

物理化学性质&存储条件

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