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首页-小分子抑制剂&激动剂-Others-Other Targets-ML390
ML390

Chemical Structure : ML390

CAS No.: 2029049-79-2

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ML390 (ML 390;ML-390)

货号: PC-42227Not For Human Use, Lab Use Only.

ML390 is a potent DHODH inhibitor that causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) AML models (ED50=2 uM).

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5 mg ￥1480 In stock
10 mg ￥2180 In stock
25 mg ￥3580 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML390 is a potent DHODH inhibitor that causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) AML models (ED50=2 uM).
ML390 but shows low solubility and bioavailability, the relative compound BRQ can be used in vivo.

物理化学性质&存储条件

分子量 406.3983
分子式 C21H21F3N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
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Solubility

DMSO: ≥ 27 mg/mL
Chemical Name/SMILES

(R)-N-(3-oxo-3-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-4-(trifluoromethoxy)benzamide

参考文献

1. Sykes DB, et al. Cell. 2016 Sep 22;167(1):171-186.e15.

2. Lewis TA, et al. ACS Med Chem Lett. 2016 Sep 28;7(12):1112-1117.

3. Sykes DB, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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