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首页-小分子抑制剂&激动剂-Others-Other Targets-ML388
ML388

Chemical Structure : ML388

CAS No.: 1537192-31-6

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ML388 (CID71307851)

货号: PC-62123Not For Human Use, Lab Use Only.

ML388 is a potent, selective NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with IC50 of 34 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ML388 is a potent, selective NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with IC50 of 34 nM.
    ML388 dispalys 71-fold selectivity versus ALDH1A1, and >1,000 fold versus LDHA, LDHB, GAPDH, and HSD17B4.
    ML388 potently promotes PGE2 production in both A549 lung cancer and LNCaP prostate cancer cells.

    物理化学性质&存储条件

    分子量 320.44
    分子式 C20H24N4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-[2,5-dimethyl-1-(4-methylphenyl)pyrrol-3-yl]-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine

    参考文献

    1. Duveau DY, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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