ML387 (CID3474778)

Chemical Structure : ML387

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货号: PC-62124Not For Human Use, Lab Use Only.

ML387 (CID3474778) is a potent, selective NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with IC50 of 19 nM.

规格	价格	库存	数量
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250 mg		Get quote

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生物&药学活性

ML387 (CID3474778) is a potent, selective NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with IC50 of 19 nM.
ML387 dispalys 71-fold selectivity versus ALDH1A1, and >1,000 fold versus LDHA, LDHB, rGAPDH, and HSD17B4.
ML387 potently promotes PGE2 production in both A549 lung cancer and LNCaP prostate cancer cells.

物理化学性质&存储条件

分子量	449.43
分子式	C22H22F3N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1-(4-methoxyphenyl)-1H-benzo[d]imidazol-5-yl)(piperidin-1-yl)methanone 2,2,2-trifluoroacetic acid

参考文献

1. Duveau DY, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].