ML378 |CAS:1831135-21-7 Probechem Biochemicals

Chemical Structure : ML378

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ML378 (CID71710938;JJH-254)

货号: PC-62332Not For Human Use, Lab Use Only.

ML378 (CID71710938, JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively.

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生物&药学活性

ML378 (CID71710938, JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively.
ML378 also inhibits ABHD6 with IC50 of 3.15 nM, and displays 13-fold and >40-fold selectivity over FAAH and 20SHs respectively.

物理化学性质&存储条件

分子量	534.01
分子式	C25H32ClN5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(Morpholine-4-carbonyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-chloro-phenethyl)piperidine-1-carboxylate

参考文献

1. Hulce JJ, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

ML378 (CID71710938;JJH-254)

生物&药学活性

物理化学性质&存储条件

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ML378 (CID71710938;JJH-254)

生物&药学活性

物理化学性质&存储条件

参考文献

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