ML368 (SR9186)

首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cytochrome P450 (CYPs)-ML368

Chemical Structure : ML368

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货号: PC-62112Not For Human Use, Lab Use Only.

ML368 (SR9186) is a potent, selective cytochrome P450 enzyme CYP3A4 inhibitor with IC50 of 4 nM (convert testosterone to hydroxytestosterone), displays >2,000-fold selectivity over CYP3A5.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML368 (SR9186) is a potent, selective cytochrome P450 enzyme CYP3A4 inhibitor with IC50 of 4 nM (convert testosterone to hydroxytestosterone), displays >2,000-fold selectivity over CYP3A5.

物理化学性质&存储条件

分子量	430.5
分子式	C26H18N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4'-cyano[1,1'-biphenyl]-4-yl)-N'-[4-(3H-imidazo[4,5-b]pyridin-7-yl)phenyl]-urea

参考文献

1. Li X, et al. Drug Metab Dispos. 2012 Sep;40(9):1803-9.

2. Towles JK, et al. Drug Metab Dispos. 2016 Oct;44(10):1584-97.

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ML368 (SR9186)

生物&药学活性

物理化学性质&存储条件

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ML368 (SR9186)

生物&药学活性

物理化学性质&存储条件

参考文献

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