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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ML365
ML365

Chemical Structure : ML365

CAS No.: 947914-18-3

ML365 (ML 365;ML-365)

货号: PC-42995Not For Human Use, Lab Use Only.

ML365 is a potent and selective inhibitor of KCNK3/TASK1 potassium channel, blocks TASK1 channels in both the thallium influx fluorescent assay (IC50=4 nM) and an automated electrophysiology assay (IC50=16 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML365 is a potent and selective inhibitor of KCNK3/TASK1 potassium channel, blocks TASK1 channels in both the thallium influx fluorescent assay (IC50=4 nM) and an automated electrophysiology assay (IC50=16 nM).
ML365 displays 98-fold selectivity over TASK1 (KCNK9), >7,500-fold over Kir2.1, KCNQ2 and hERG in thallium influx fluorescent assay.
ML365 is a useful pharmacological probe for in vitro studies of TASK1 function.

物理化学性质&存储条件

分子量 360.4058
分子式 C22H20N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]-

参考文献

1. Zou B, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Skarsfeldt MA, et al. Pflugers Arch. 2016 Apr;468(4):643-54.

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