ML358 | SKN-1 inhibitor | Probechem Biochemicals

Chemical Structure : ML358

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ML358 (ML 358)

货号: PC-62388Not For Human Use, Lab Use Only.

ML358 is a first in class, selective small molecule inhibitor of the SKN-1 pathway with IC50 of 0.24 uM.

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生物&药学活性

ML358 is a first in class, selective small molecule inhibitor of the SKN-1 pathway with IC50 of 0.24 uM.
ML358 shows inactivity against Nrf2, the homologous mammalian detoxification pathway, and is not toxic to C. elegans (LC50 > 64 uM) and Fa2N-4 immortalized human hepatocytes (LC50 > 5.0 uM).
ML358 sensitizes the model nematode C. elegans to oxidants and anthelmintics.
ML358 exhibits good solubility, permeability, and chemical and metabolic stability in human and mouse liver microsomes.
ML358 a valuable chemical probe to study regulation and function of SKN-1 in vivo.

物理化学性质&存储条件

分子量	430.794
分子式	C21H26Cl3NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-chloro-4-((4-chlorobenzyl)-oxy)-5-ethoxybenzyl)-cyclopentanamine hydrochloride

参考文献

1. Peddibhotla S, et al. ACS Chem Biol. 2015 Aug 21;10(8):1871-9.

2. Peddibhotla S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

ML358 (ML 358)

生物&药学活性

物理化学性质&存储条件

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ML358 (ML 358)

生物&药学活性

物理化学性质&存储条件

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