欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Lipoxygenase-ML355
ML355

Chemical Structure : ML355

CAS No.: 1532593-30-8

加入收藏

ML355 (VLX-1005, ML-355, VLX1005)

货号: PC-42990Not For Human Use, Lab Use Only.

ML355 (VLX-1005) is a potent, and selective inhibitor of human 12-Lipoxygenase (12-LOX) with IC50 of 290 nM.

规格 价格 库存 数量
10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg ￥5280 In stock
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML355 (VLX-1005) is a potent, and selective inhibitor of human 12-Lipoxygenase (12-LOX) with IC50 of 290 nM.
ML355 displays >100-fold selectivity over 15-LOX-1, 15-LOX-2, 5-LOX and COX1, COX2.
ML355 has favorable ADME properties, inhibits PAR-4 induced aggregation and calcium mobilization in human platelets, and reduces 12-HETE in mouse/human beta cells.

物理化学性质&存储条件

分子量 441.5233
分子式 C21H19N3O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 42 mg/mL
Chemical Name/SMILES

Benzenesulfonamide, N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-

参考文献

1. Luci D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Ma K, et al. J Clin Endocrinol Metab. 2017 May 10. doi: 10.1210/Jc.2017-00267.

3. Luci DK, et al. J Med Chem. 2014 Jan 23;57(2):495-506.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: