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首页-小分子抑制剂&激动剂-GPCR-mGluR-ML353
ML353

Chemical Structure : ML353

CAS No.: 2990506-75-5

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ML353 (VU0478006, ML353, VU 0478006)

货号: PC-62120Not For Human Use, Lab Use Only.

ML353 (VU0478006) is a highly potent, selective, MPEP-site silent allosteric modulator of mGlu5 receptor with with sub-100 nM affinity.

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5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML353 (VU0478006) is a highly potent, selective, MPEP-site silent allosteric modulator of mGlu5 receptor with with sub-100 nM affinity.
ML353 (VU0478006) displays >200-fold selectivity over mGlu1, 2-4, 6-8, and >20-fold improvement over the prior mGlu5 SAM tool compound 5MPEP.

物理化学性质&存储条件

分子量 306.34
分子式 C19H15FN2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-azabicyclo[3.1.0]hexan-3-yl(5-((3-fluorophenyl)ethynyl)pyridin-2-yl)methanone

参考文献

1. Gregory KJ, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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