ML350 | KOR antagonist | Probechem Biochemicals

Chemical Structure : ML350

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ML350 (ML 350, CYM 50202)

货号: PC-62111Not For Human Use, Lab Use Only.

ML350 (CYM 50202) is a highly potent and selective Opioid kappa receptor (OPRK1/KOR) antagonist with IC50 of 9-16 nM.

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生物&药学活性

ML350 (CYM 50202) is a highly potent and selective Opioid kappa receptor (OPRK1/KOR) antagonist with IC50 of 9-16 nM.
ML350 displays 219-382–fold and 20-35–fold selectivity over OPRD1 and OPRM1, respectively.
ML350 has high passive membrane permeability, good brain penetration, no significant activity at three of four human cytochrome P450 subtypes, high binding for rodent plasma protein and modest binding for human plasma protein, and an encouraging in vivo pharmacokinetic profile in rats.
ML350 has a reversible analgesic effect when challenged with an OPRK agonist (U-69593) in a tail flick assay in mice.

物理化学性质&存储条件

分子量	412.328
分子式	C18H26BrN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 5-bromo-2-[trans-4-(cyclohexylamino)-3-hydroxypiperidin-1-yl]pyridine-3-carboxylate

参考文献

1. Guerrero M, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

ML350 (ML 350, CYM 50202)

生物&药学活性

物理化学性质&存储条件

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ML350 (ML 350, CYM 50202)

生物&药学活性

物理化学性质&存储条件

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