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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phospholipase-ML349
ML349

Chemical Structure : ML349

CAS No.: 890819-86-0

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ML349 (ML-349, ML 349)

货号: PC-60917Not For Human Use, Lab Use Only.

ML349 is a potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM, >20-fold selectivity over APT-1 and serine hydrolase enzyme family.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML349 is a potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM.
ML349 displays >20-fold selectivity over APT-1 and serine hydrolase enzyme family.
ML349 is an useful chemical probe for investigations into the biological function of LYPLA1 and LYPLA2.

物理化学性质&存储条件

分子量 454.56
分子式 C23H22N2O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 20 mg/mL
Chemical Name/SMILES

(5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone

参考文献

1. Won SJ, et al. ACS Chem Biol. 2016 Dec 16;11(12):3374-3382.

2. Vujic I, et al. Oncotarget. 2016 Feb 9;7(6):7297-306.

3. Won SJ, et al. ACS Med Chem Lett. 2016 Dec 9;8(2):215-220.

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