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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phospholipase-ML348
ML348

Chemical Structure : ML348

CAS No.: 899713-86-1

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ML348 (ML-348, GNF-Pf-1127)

货号: PC-42240Not For Human Use, Lab Use Only.

ML348 is a potent, selective Acyl protein thioesterase 1 (APT-1, LYPLA1) with IC50 of 210 nM, displays >10-fold selectivity over APT-2, >47-fold selectivity over a panel of >20 serine hydrolases.

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5 mg (Free Sample) ￥180 In stock
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML348 is a potent, selective Acyl protein thioesterase 1 (APT-1, LYPLA1) with IC50 of 210 nM, displays >10-fold selectivity over APT-2, >47-fold selectivity over a panel of >20 serine hydrolases.
ML348 shows no biologically significant effects in NRAS mutant melanoma cells.

物理化学性质&存储条件

分子量 415.7941
分子式 C18H17ClF3N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Piperazineacetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-

参考文献

1. Adibekian A, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Vujic I, et al. Oncotarget. 2016 Feb 9;7(6):7297-306.

3. Won SJ, et al. ACS Chem Biol. 2016 Dec 16;11(12):3374-3382.

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