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首页-小分子抑制剂&激动剂-Others-Other Targets-ML345
ML345

Chemical Structure : ML345

CAS No.: 1632125-79-1

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ML345 (ML-345)

货号: PC-25784Not For Human Use, Lab Use Only.

ML345 is a potent, selective Insulin-degrading enzyme (IDE, Insulysin) with IC50 of 188 nM, targets a specific cysteine residue (Cys819) in IDE, also is a highly potent and selective NLRP3 inhibitor, directly targets tyrosine 381 (Y381) and disrupts its essential interaction with NIMA-related kinase 7 (NEK7).

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5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML345 is a potent, selective Insulin-degrading enzyme (IDE, Insulysin) with IC50 of 188 nM, targets a specific cysteine residue (Cys819) in IDE, also is a highly potent and selective NLRP3 inhibitor, directly targets tyrosine 381 (Y381) and disrupts its essential interaction with NIMA-related kinase 7 (NEK7).
inhibits IL-1β release in immortalized BMDMs (iBMDMs) with IC50 of 197.7 nM.
ML345 potently blocks inflammasome-driven cytokine maturation and pyroptosis.
ML345 dose-dependently reduced IL-1β secretion without altering TNF production in primary human PBMCs stimulated with nigericin.
ML345 selectively inhibits NLRP3 inflammasome activation without affecting other inflammasomes (NLRP6, NLRP1/CARD8, or Pyrin inflammasomes).
ML345 disrupts the NEK7-NLRP3 interaction to prevent inflammasome activation, which is independent of IDE.
ML345 inhibits LPS-induced systemic inflammation and miscarriage in mouse models of systemic inflammation and miscarriage.

物理化学性质&存储条件

分子量 479.54
分子式 C21H22FN3O5S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one

参考文献

1. Bannister TD, et al. 2012 Dec 17 [updated 2014 May 13]. In: Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Lin H, et al. Mol Biomed. 2025 Nov 13;6(1):108.

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