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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Other Viruses-ML336
ML336

Chemical Structure : ML336

CAS No.: 1613465-33-0

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ML336 (ML 336)

货号: PC-38481Not For Human Use, Lab Use Only.

ML336 is a highly potent small molecule inhibitor of enezuelan equine encephalitis virus (VEEV) with EC50 of 0.02-0.04 uM.

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5 mg ￥2380 In stock
10 mg ￥3780 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML336 is a highly potent small molecule inhibitor of enezuelan equine encephalitis virus (VEEV) with EC50 of 0.02-0.04 uM.
ML336 potently inhibits VEEV RNA synthesis with IC50 of 1.1 nM, but not Old World alphavirus Chikungunya virus (IC50>4 uM).
ML336 inhibits the synthesis of the positive sense genomic, negative sense template, and subgenomic RNAs of VEEV. ML336 shows significant protection and inhibits viral replication in vivo in VEEV-infected mice (5 mg/kg/day).
ML336 appears to inhibit viral replication through a unique pathway involving interference with viral nonstructural proteins 2 and 4, or inhibits viral RNA synthesis through interaction with the viral replicase complex.

物理化学性质&存储条件

分子量 367.409
分子式 C19H21N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide

参考文献

1. Schroeder CE, et al. J Med Chem. 2014 Oct 23;57(20):8608-21.

2. Chung D, et al. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

3. Jonsson CB, et al. Antiviral Res. 2019 Jul;167:25-34.

4. Skidmore AM, et al. Antiviral Res. 2020 Feb;174:104674.

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