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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ML335
ML335

Chemical Structure : ML335

CAS No.: 825658-06-8

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ML335 (ML 335;ML-335)

货号: PC-60337Not For Human Use, Lab Use Only.

ML335 (ML 335) is anovel potent, selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channels activator with EC50 of 14.3 and 5.2 uM, respectively.

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50 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML335 (ML 335) is anovel potent, selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channels activator with EC50 of 14.3 and 5.2 uM, respectively.
ML335 displays no significant activity for K2P4.1 (at 50 uM); shows insensitivity to mutant K2P2.1(K271Q) , and has similar EC50 for K2P4.1(Q258K) (EC50=16.7 uM).

物理化学性质&存储条件

分子量 373.248
分子式 C15H14Cl2N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(2,4-dichlorophenyl) methyl]-4-(methanesulfonamido) benzamide

参考文献

1. Lolicato M, et al. Nature. 2017 Jul 20;547(7663):364-368.

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