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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-ML334
ML334

Chemical Structure : ML334

CAS No.: 1432500-66-7

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ML334 (LH601A, (SRS)-5)

货号: PC-22765Not For Human Use, Lab Use Only.

ML334 (LH601A) is a cell permeable inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction (PPI) with ARE-inducing EC50 of 18 uM, promotes the nuclear translocation of Nrf2 with EC50 of 12 uM in Keap1-Nrf2 functional assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ML334 (LH601A) is a cell permeable inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction (PPI) with ARE-inducing EC50 of 18 uM, promotes the nuclear translocation of Nrf2 with EC50 of 12 uM in Keap1-Nrf2 functional assay.
ML334 binds to Keap1 Kelch domain, inhibits the Keap1-Nrf2 protein-protein interaction by non-covalent binding.

物理化学性质&存储条件

分子量 446.50
分子式 C26H26N2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
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Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid

参考文献

1. Hu L, et al. Bioorg Med Chem Lett. 2013 May 15;23(10):3039-43.

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