ML325 | pan-PAD inhibitor | Probechem Biochemicals

Chemical Structure : ML325

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ML325 (ML 325)

货号: PC-20331Not For Human Use, Lab Use Only.

ML325 (ML 325) is a potent, irreversible pan-protein arginine deiminase (PAD) inhibitor with IC50 of 70 nM, 200 nM 170 nM, and 240 nM for PAD1, 2, 3, and 4 in vitro respectively.

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生物&药学活性

ML325 (ML 325) is a potent, irreversible pan-protein arginine deiminase (PAD) inhibitor with IC50 of 70 nM, 200 nM 170 nM, and 240 nM for PAD1, 2, 3, and 4 in vitro respectively.
ML325 has kinact/KI values of 3500, 7300, 1900, and 5300 M−1min−1 for PAD1, 2, 3 and 4 respectively, 4-fold selectivity among the four family members.
ML325 exhibits high selectivity over > 20 cysteine-reactive proteins as assayed by activity-based protein profiling.

物理化学性质&存储条件

分子量	295.25
分子式	C15H9N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(7-amino-5,8-dioxo-5,8-dihydroquinolin-2-yl)picolinic acid

参考文献

1. Christina J Dreyton, et al. Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor.

ML325 (ML 325)

生物&药学活性

物理化学性质&存储条件

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ML325 (ML 325)

生物&药学活性

物理化学性质&存储条件

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