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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cdc2-like Kinase (CLK)-ML315
ML315

Chemical Structure : ML315

CAS No.: 1440251-53-5

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ML315 (ML 315)

货号: PC-20756Not For Human Use, Lab Use Only.

ML315 is a small molecule inhibitor of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases with IC50 of 68, 231, >10,000, 68, 282 and 1156 nM for CLK1/2/3/4 and DYRK1/2, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ML315 is a small molecule inhibitor of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases with IC50 of 68, 231, >10,000, 68, 282 and 1156 nM for CLK1/2/3/4 and DYRK1/2, respectively.

物理化学性质&存储条件

分子量 374.22
分子式 C18H13Cl2N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ClC1=CC(Cl)=CC(CNC2=NC=NC=C2C3=CC=C(OCO4)C4=C3)=C1

参考文献

1. Coombs TC, et al. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3654-61.

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