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首页-小分子抑制剂&激动剂-GPCR-Neurotensin Receptor-ML314
ML314

Chemical Structure : ML314

CAS No.: 1448895-09-7

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ML314 (ML 314)

货号: PC-20493Not For Human Use, Lab Use Only.

ML314 is a selective, brain penetrant full agonist of neurotensin 1 receptor (NTR1) with EC50 of 2.0 uM, shows good selectivity against NTR2 and GPR35.

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5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥3280 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML314 is a selective, brain penetrant full agonist of neurotensin 1 receptor (NTR1) with EC50 of 2.0 uM, shows good selectivity against NTR2 and GPR35.
ML314 is potentially a biased agonist operating via the β-arrestin pathway rather than the traditional Gq coupled pathway.

物理化学性质&存储条件

分子量 420.51
分子式 C24H28N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline

参考文献

1. Peddibhotla S, et al. ACS Med Chem Lett. 2013 Jul 20;4(9):846-851.

2. Barak LS, et al. ACS Chem Biol. 2016 Jul 15;11(7):1880-90.

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