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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ML308
ML308

Chemical Structure : ML308

CAS No.: 1212238-62-4

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ML308 (ML 308)

货号: PC-20702Not For Human Use, Lab Use Only.

ML308 (ML 308) is a potent, selective inhibitor of two-pore domain potassium channel KCNK9 (TASK-3, K2P9.1) with IC50 of 130 nM in thallium influx fluorescent assays and 413 nM in automated electrophysiology assays, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML308 (ML 308) is a potent, selective inhibitor of two-pore domain potassium channel KCNK9 (TASK-3, K2P9.1) with IC50 of 130 nM in thallium influx fluorescent assays and 413 nM in automated electrophysiology assays, respectively.
ML308 displays >50-fold selectivity over the closely-related, two-pore domain potassium channel, KCNK3, in fluorescent assays and displays little or no activity at 10 μM for Kir2.1, KCNQ2, and human ether-a go-go-related gene (HERG).
ML308 is a useful pharmacological probe for in vitro studies of KCNK9 function.

物理化学性质&存储条件

分子量 289.40
分子式 C15H19N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

SC1=NN=C(C2=CC=CO2)N1[C@H]([C@H]3[C@](C4)([H])CC[C@]4([H])C3)C

参考文献

1. Miller MR, et al. National Center for Biotechnology Information (US); 2010–.

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