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首页-小分子抑制剂&激动剂-GPCR-Neurotensin Receptor-ML301
ML301

Chemical Structure : ML301

CAS No.: 1531633-84-7

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ML301 (ML 301)

货号: PC-20492Not For Human Use, Lab Use Only.

ML301 is a selective full (79-93%) neurotensin-1 (NTR1) receptor agonist with EC50 of 2.0-4.1 uM, good selectivity relative to NTR2 and GPR35.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ML301 is a selective full (79-93%) neurotensin-1 (NTR1) receptor agonist with EC50 of 2.0-4.1 uM, good selectivity relative to NTR2 and GPR35.
    ML301 showed good activity in a Ca mobilization FLIPR assay (93% efficacy at 298 nM), consistent with it functioning via the Gq coupled pathway.

    物理化学性质&存储条件

    分子量 522.99
    分子式 C27H27ClN4O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    CC(C)C[C@@H](C(O)=O)NC(C1=CN(C2=CC=NC3=CC(Cl)=CC=C23)C(C4=C(OC)C=CC=C4OC)=N1)=O

    参考文献

    1. Hershberger PM, et al. Bioorg Med Chem Lett. 2014 Jan 1;24(1):262-7.

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