ML299 |CAS:1426916-00-8 Probechem Biochemicals

Chemical Structure : ML299

CAS No.: 1426916-00-8

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ML299 (VU0463568; ML-299)

货号: PC-62136Not For Human Use, Lab Use Only.

ML299 (VU0463568) is a potent, CNS penetrant, dual phospholipase PLD1/PLD2 probe inhibitor with IC50 of 6 nM/20 nM, respectively.

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10 mg	￥2480	In stock
25 mg	￥4280	In stock
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200 mg		Get quote

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生物&药学活性

ML299 (VU0463568) is a potent, CNS penetrant, dual phospholipase PLD1/PLD2 probe inhibitor with IC50 of 6 nM/20 nM, respectively.
ML299 (VU0463568) robustly increases caspase 3/7 activation under serum-free conditions, provides a dose-dependent decrease (100 nM to 10 uM) in invasive migration in U87-MG cells, with statistical significance reached at both the 1 uM and 10 uM doses.

物理化学性质&存储条件

分子量	489.4
分子式	C23H26BrFN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]-benzamide

参考文献

1. Scott SA, et al. Nat Chem Biol. 2009 Feb;5(2):108-17.

2. O'Reilly MC, et al. J Med Chem. 2013 Mar 28;56(6):2695-9.

3. Scott SA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

ML299 (VU0463568; ML-299)

生物&药学活性

物理化学性质&存储条件

参考文献

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ML299 (VU0463568; ML-299)

生物&药学活性

物理化学性质&存储条件

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