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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phospholipase-ML298
ML298

Chemical Structure : ML298

CAS No.: 1426916-02-0

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ML298 (CID53393915, ML-298)

货号: PC-62137Not For Human Use, Lab Use Only.

ML298 is a potent, selective phospholipase PLD2 inhibitor with IC50 of 355 nM, displays >53-fold selectivity over PLD1 (IC50>20 uM).

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML298 is a potent, selective phospholipase PLD2 inhibitor with IC50 of 355 nM, displays >53-fold selectivity over PLD1 (IC50>20 uM).
ML298 decreases invasive migration in U87-MG glioblastoma cells; has an attractive DMPK profile.
ML298 is an attractive tool compound to further dissect PLD2 function in multiple cellular and in vivo environments.

物理化学性质&存储条件

分子量 432.44
分子式 C22H23F3N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-benzamide

参考文献

1. O'Reilly MC, et al. J Med Chem. 2013 Mar 28;56(6):2695-9.

2. Scott SA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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