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ML283

Chemical Structure : ML283

CAS No.: 1403245-31-7

ML283

货号: PC-24071Not For Human Use, Lab Use Only.

ML283 is a potent, specific inhibitor of HCV non-structural protein 3 (NS3) helicase with IC50 of 2.6 uM (HCV genotype 1b), also inhibits DENV NS3-catalyzed RNA unwinding, also is a potent SARS-CoV-2 nsp13 helicase inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ML283 is a potent, specific inhibitor of HCV non-structural protein 3 (NS3) helicase with IC50 of 2.6 uM (HCV genotype 1b), also inhibits DENV NS3-catalyzed RNA unwinding, also is a potent SARS-CoV-2 nsp13 helicase inhibitor.

物理化学性质&存储条件

分子量 609.13
分子式 C28H21ClN4O4S3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

[2,6'-Bibenzothiazole]-7-sulfonic acid, 2'-[4-[(3-chlorobenzoyl)amino]phenyl]-6-methyl-, ammonium salt (1:1)

参考文献

1. Sweeney NL, et al. ACS Infect Dis. 2015 Mar 13;1(3):140-148.

2. Li K, et al. Hepatitis C Virus NS3 Helicase Inhibitor Discovery.

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