ML254 (VU0430644)

Chemical Structure : ML254

CAS No.: 1428630-86-7

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货号: PC-38454Not For Human Use, Lab Use Only.

ML254 (VU0430644) is a potent, selective metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator with EC50 of 9.3 nM.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

ML254 (VU0430644) is a potent, selective metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator with EC50 of 9.3 nM.
ML254 is highly selective for mGlu5 versus other mGlu receptors, as well as a panel of 68 GPCRs, ion channels and transporters.
ML254 demonstrates a robust reversal of amphetamine induced hyperlocomotion at a single dose in an in vivo model of psychosis.

物理化学性质&存储条件

分子量	310.32
分子式	C18H15FN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[2-(3-Fluorophenyl)ethynyl]-N-(3-methyl-3-oxetanyl)-2-pyridinecarboxamide

参考文献

1. Turlington M, et al. J Med Chem. 2013 Oct 24;56(20):7976-96.

2. Zhou Y, et al. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

ML254 (VU0430644)

生物&药学活性

物理化学性质&存储条件

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ML254 (VU0430644)

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物理化学性质&存储条件

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