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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ML252
ML252

Chemical Structure : ML252

CAS No.: 1392494-64-2

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ML252 (ML 252 )

货号: PC-20943Not For Human Use, Lab Use Only.

ML252 is a potent and selective, brain penetrant inhibitor of KCNQ2 (Kv 7.2) with IC50 of 69 nM, EC50 of 170 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ML252 is a potent and selective, brain penetrant inhibitor of KCNQ2 (Kv 7.2) with IC50 of 69 nM, EC50 of 170 nM.
ML252 is >40-fold selective versus KCNQ1.

物理化学性质&存储条件

分子量 308.43
分子式 C20H24N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

CC[C@@H](C1=CC=CC=C1)C(NC2=CC=CC=C2N3CCCC3)=O

参考文献

1. Yiu-Yin Cheung, et al. J Med Chem. 2012 Aug 9;55(15):6975-9.

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