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首页-小分子抑制剂&激动剂-Others-Other Targets-ML250
ML250

Chemical Structure : ML250

CAS No.: 1421365-63-0

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ML250 (ML 250, CYM50769)

货号: PC-38611Not For Human Use, Lab Use Only.

ML250 (CYM 50769) is a potent and selective GPR7 (Neuropeptides B/W receptor 1, NPBWR1) antagonist probe, inhibits human GPR7 expression in the presence of GPR7 agonist NPW with IC50 value of 124 nM-244 nM, displays 82- >161 fold selectivity over MCH1.

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25 mg ￥2780 In stock
50 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML250 (CYM 50769) is a potent and selective GPR7 (Neuropeptides B/W receptor 1, NPBWR1) antagonist probe, inhibits human GPR7 expression in the presence of GPR7 agonist NPW with IC50 value of 124 nM-244 nM, displays 82- >161 fold selectivity over MCH1.

物理化学性质&存储条件

分子量 416.861
分子式 C24H17ClN2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy)pyridazin-3(2H)-one

参考文献

1. Miguel Guerrero, et al. In: Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Miguel Guerrero, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):614-9.

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