ML239 |CAS:1378872-36-6 Probechem Biochemicals

Chemical Structure : ML239

CAS No.: 1378872-36-6

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ML239 (ML 239, CID49843203)

货号: PC-62221Not For Human Use, Lab Use Only.

ML239 is a selective small molecule inhibitor of breast cancer stem cells with IC50 of 1.18 uM, displays >23-fold selective inhibition of the breast CSC-like cell line over the isogenic control cell line.

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25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

ML239 is a selective small molecule inhibitor of breast cancer stem cells (CSCs) with IC50 of 1.18 uM, displays >23-fold selective inhibition of the breast CSC-like cell line over the isogenic control cell line.
ML239 alters the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways.
ML239 most likely acts through activation of fatty acid desaturase 2 (FADS2).

物理化学性质&存储条件

分子量	346.592
分子式	C13H10Cl3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,4,6-trichlorophenoxy)-acetic acid, (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide

参考文献

1. Rees MG, et al. Nat Chem Biol. 2016 Feb;12(2):109-16.

2. Carmody LC, et al. J Biomol Screen. 2012 Oct;17(9):1204-10.

3. Germain AR, et al. Bioorg Med Chem Lett. 2012 May 15;22(10):3571-4.

ML239 (ML 239, CID49843203)

生物&药学活性

物理化学性质&存储条件

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ML239 (ML 239, CID49843203)

生物&药学活性

物理化学性质&存储条件

参考文献

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