ML236 | NF-κB inhibitor | Probechem Biochemicals

Chemical Structure : ML236

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ML236 (ML-236)

货号: PC-38805Not For Human Use, Lab Use Only.

ML236 is a potent, B-cell specific NF-κB inhibitor with IC50 of 35 nM, selective for the NF-κB pathway induced by PKC activators (phorbol myristic acetate/ionomycin) and selective for B-cells.

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生物&药学活性

ML236 is a potent, B-cell specific NF-κB inhibitor with IC50 of 35 nM, selective for the NF-κB pathway induced by PKC activators (phorbol myristic acetate/ionomycin) and selective for B-cells.
ML236 displays >400-fold selective over both the NF-κB activation in T-cells and against TNFα-mediated NF-κB activation.

物理化学性质&存储条件

分子量	287.363
分子式	C16H21N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazol-5-yl)-N-methylpropanamide

参考文献

1. Pu J, et al. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

2. Lee HH, et al. Cancers (Basel). 2019 Dec 30;12(1):98.

ML236 (ML-236)

生物&药学活性

物理化学性质&存储条件

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ML236 (ML-236)

生物&药学活性

物理化学性质&存储条件

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