ML233

Chemical Structure : ML233

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货号: PC-24284Not For Human Use, Lab Use Only.

ML233 is a small molecule apelin receptor (APJ, APLNR)) agonist, also is a potent inhibitor of tyrosinase (TYR) activity in vivo and in vitro.

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100 mg		Get quote

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生物&药学活性

ML233 is a small molecule apelin receptor (APJ, APLNR)) agonist, also is a potent inhibitor of tyrosinase (TYR) activity in vivo and in vitro.
ML233 shows protective effect against retinal neuronal cell death induced by the intravitreal injection of NMDA into mice.
ML233 prevented the NMDA-induced reduction in the amplitude of scotopic threshold responses (STR).
ML233 inhibited the NMDA-induced loss of retinal ganglion cells and amacrine cells.
ML233 increased the phosphorylation of Akt, a potent anti-apoptotic protein in neurons, in the retina.
ML233 inhibited ME1154B viability/proliferation (IC50 = 1.65 μM).
ML233 inhibit proliferation of human metastatic melanoma in PDXO in vitro models.

物理化学性质&存储条件

分子量	359.44
分子式	C19H21NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Cyclohexyl-2-methyl-2,5-cyclohexadiene-1,4-dione 1-[O-(phenylsulfonyl)oxime]

参考文献

1. Menard R, et al. bioRxiv [Preprint]. 2025 Feb 20:2025.02.16.638443.

2. Shibagaki F, et al. Neurochem Res. 2020 Apr;45(4):752-759.

ML233

生物&药学活性

物理化学性质&存储条件

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ML233

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