ML228 | HIF activator | Probechem Biochemicals

Chemical Structure : ML228

CAS No.: 1357171-62-0

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ML228 (ML-228;CID-46742353)

货号: PC-43179Not For Human Use, Lab Use Only.

ML228 (ML-228, CID-46742353) is an activator of the hypoxia inducible factor (HIF) pathway with EC50 of 1.4 uM in HIF-1α nuclear translocation assays.

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2480	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

ML228 (ML-228, CID-46742353) is an activator of the hypoxia inducible factor (HIF) pathway with EC50 of 1.4 uM in HIF-1α nuclear translocation assays.
ML228 demonstrates to potently activate HIF in vitro as well as its downstream target VEGF (EC50=1.63 uM).
ML228 significantly augmentes VEGFR-2, attenuates Caspase-3 and neuronal apoptosis, and improves neurological Severity Score and tissue edema in the hippocampus of rats, without affecting expression of NF-κB.

物理化学性质&存储条件

分子量	415.4891
分子式	C27H21N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 35 mg/mL
Chemical Name/SMILES	1,2,4-Triazin-5-amine, N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-

参考文献

1. Theriault JR, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):76-81.

2. Liu XL, et al. Life Sci. 2016 Apr 15;151:243-249.

3. Zhao Y, et al. Sci Rep. 2016 Aug 23;6:31952.

ML228 (ML-228;CID-46742353)

生物&药学活性

物理化学性质&存储条件

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ML228 (ML-228;CID-46742353)

生物&药学活性

物理化学性质&存储条件

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