ML226 (ML-226)

Chemical Structure : ML226

CAS No.: 2055172-43-3

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货号: PC-38533Not For Human Use, Lab Use Only.

ML226 (ML-226) is a potent, selective, covalent inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with IC50 values of 15 and 0.68 nM in vitro and in situ, respectively.

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5 mg	￥3980	In stock
10 mg	￥5980	In stock
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生物&药学活性

ML226 (ML-226) is a potent, selective, covalent inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with IC50 values of 15 and 0.68 nM in vitro and in situ, respectively.
ML226 is 100-fold selective for ABHD11 over approximately 20 other serine hydrolases.
ML226 covalently carbamoylates the active site serine of ABHD11.

物理化学性质&存储条件

分子量	390.5
分子式	C23H26N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-ethyl-1-piperidinyl)[4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-methanone

参考文献

1. Hsu KL, et al. Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6). 2012 Apr 12 [updated 2013 Mar 14]. In: Probe Reports from the NIH Molecular Libraries Program [Internet].

ML226 (ML-226)

生物&药学活性

物理化学性质&存储条件

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ML226 (ML-226)

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物理化学性质&存储条件

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