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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phospholipase-ML226
ML226

Chemical Structure : ML226

CAS No.: 2055172-43-3

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ML226 (ML 226)

货号: PC-38533Not For Human Use, Lab Use Only.

ML226 is a potent, selective, covalent inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with IC50 values of 15 and 0.68 nM in vitro and in situ, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML226 is a potent, selective, covalent inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with IC50 values of 15 and 0.68 nM in vitro and in situ, respectively.
ML226 is 100-fold selective for ABHD11 over approximately 20 other serine hydrolases.
ML226 covalently carbamoylates the active site serine of ABHD11.

物理化学性质&存储条件

分子量 390.5
分子式 C23H26N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2-ethyl-1-piperidinyl)[4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-methanone

参考文献

1. Adibekian, A.,et al. Anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211. Probe Reports from the NIH Molecular Libraries Program (2010).

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