ML221 |CAS: 877636-42-5 Probechem Biochemicals

Chemical Structure : ML221

CAS No.: 877636-42-5

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ML221 (ML 221)

货号: PC-63277Not For Human Use, Lab Use Only.

ML221 is a potent, selective, functional antagonist of apelin receptor (APJ) with IC50 of 1.75 uM in the β-arrestin assay, >37-fold selective over the closely related AT1 receptor.

规格	价格	库存
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

ML221 is a potent, selective, functional antagonist of apelin receptor (APJ) with IC50 of 1.75 uM in the β-arrestin assay, >37-fold selective over the closely related AT1 receptor.
ML221 inhibits apelin-13-mediated activation of APJ in cAMP assays with IC50 of 0.7 uM.
ML221 inhibits cholangiocarcinoma proliferation and angiogenesis, significantly decreases tumor growth in nu/nu mice.

物理化学性质&存储条件

分子量	385.35
分子式	C17H11N3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one

参考文献

1. Maloney PR, et al. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6656-60.

2. Sakamoto K, et al. Eur J Pharmacol. 2016 Nov 15;791:213-220.

3. Ishimaru Y, et al. Sci Rep. 2017 Nov 8;7(1):15062.

4. Hall C, et al. Cancer Lett. 2017 Feb 1;386:179-188.

ML221 (ML 221)

生物&药学活性

物理化学性质&存储条件

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ML221 (ML 221)

生物&药学活性

物理化学性质&存储条件

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