ML210 (ML-210) | GPX4 inhibitor | Probechem Biochemicals

Chemical Structure : ML210

CAS No.: 1360705-96-9

加入收藏

ML210 (ML-210, CID 49766530)

货号: PC-38298Not For Human Use, Lab Use Only.

ML210 (ML-210, CID 49766530) is a small-molecule probe that selectively kill cells induced to express mutant RAS.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ML210 (ML-210, CID 49766530) is a small-molecule probe that selectively kill cells induced to express mutant RAS.
ML210 is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 30 nM.
ML210 displays nanomolar potency (IC50=71 nM) against immortalized BJ fibroblasts expressing HRASV12.
ML-210 binds the GPX4 selenocysteine residue.
ML210 exhibits cell-killing activity similar to RSL3 and ML162 across a panel of 821 cancer cell lines.

物理化学性质&存储条件

分子量	475.32
分子式	C22H20Cl2N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone

参考文献

1. Joshua A Bittker, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2011

2. Weïwer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.

3. Zhou L, et al. Small. 2021 Nov;17(47):e2103919.

4. John K Eaton, et al. Nat Chem Biol. 2020 May;16(5):497-506.

ML210 (ML-210, CID 49766530)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ML210 (ML-210, CID 49766530)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.