ML204 |CAS:5465-86-1 Probechem Biochemicals

Chemical Structure : ML204

CAS No.: 5465-86-1

加入收藏

ML204 (ML-204)

货号: PC-43288Not For Human Use, Lab Use Only.

ML204 is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel.

规格	价格	库存
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg	￥2480	In stock
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ML204 is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel.
ML204 blocks TRPC4β currents activated through either μ-opioid receptor stimulation (50 nm DAMGO, IC50=3.55 uM) or intracellular dialysis of GTPγS (IC50=2.85 uM).
ML204 shows no appreciable block by 10-20 uM for TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and Nav Channels.
ML204 also inhibits TRPC5 channel currents activated through co-stimulation of Gi/o and Gq/11 signaling by μ-opioid and M3-like muscarinic receptors.

物理化学性质&存储条件

分子量	226.3168
分子式	C15H18N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 37 mg/mL
Chemical Name/SMILES	Quinoline, 4-methyl-2-(1-piperidinyl)-

参考文献

1. Miller M, et al. J Biol Chem. 2011 Sep 23;286(38):33436-46.

2. Zhang L, et al. Neuropharmacology. 2013 Sep;72:106-15.

3. Carson C, et al. PLoS One. 2015 Jun 22;10(6):e0127498.

4. Alawi KM, et al. Ann Rheum Dis. 2017 Jan;76(1):252-260.

ML204 (ML-204)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ML204 (ML-204)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.