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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-ML2-SA1
ML2-SA1

Chemical Structure : ML2-SA1

CAS No.:

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ML2-SA1 (EVP-22)

货号: PC-72671Not For Human Use, Lab Use Only.

ML2-SA1 is a potent, selective and efficacious activator (agonist) of TRPML2 with EC50 of 1.24 uM and 2.38 uM for human and mouse TRPML2, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ML2-SA1 is a potent, selective and efficacious activator (agonist) of TRPML2 with EC50 of 1.24 uM and 2.38 uM for human and mouse TRPML2, respectively.
    ML2-SA1 displays high selectivity for TRPML2 and no significant activity at the related TRPML1 and TRPML3 channels.
    ML2-SA1 directly stimulates release of the chemokine CCL2 from macrophages, also stimulates macrophage migration, thus mimicking CCL2 function.

    物理化学性质&存储条件

    分子量 282.2
    分子式 C14H13Cl2NO
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(2,6-Dichlorophenyl)-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene

    参考文献

    1. Plesch E, et al. Elife. 2018 Nov 27;7:e39720.

    2. Santoni G, et al. Int J Mol Sci. 2022 Jan 8;23(2):688.

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