ML197 |CAS:1222891-88-4 Probechem Biochemicals

Chemical Structure : ML197

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ML197 (NCGC00185963;ML 197)

货号: PC-63477Not For Human Use, Lab Use Only.

ML197 (NCGC00185963) is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.

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生物&药学活性

ML197 (NCGC00185963) is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.
ML197 inhibits CLK2, CLK3 and Dyrk1B with IC50 of 1327, 7448 and 1510 nM.
ML197 extends intracellular NKX3.1 half-life in LNCaP prostate cancer cells;

物理化学性质&存储条件

分子量	376.434
分子式	C20H16N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4-yl)methyl)quinazolin-4-amine

参考文献

1. Rosenthal AS, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3152-8.

2. Ewton DZ, et al. Mol Cancer Ther. 2011 Nov;10(11):2104-14.

3. Rosenthal AS, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

ML197 (NCGC00185963;ML 197)

生物&药学活性

物理化学性质&存储条件

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ML197 (NCGC00185963;ML 197)

生物&药学活性

物理化学性质&存储条件

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