ML193 |CAS:713121-80-3 Probechem Biochemicals

Chemical Structure : ML193

CAS No.: 713121-80-3

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ML193 (ML 193;ML-193;CID 1261822)

货号: PC-35195Not For Human Use, Lab Use Only.

ML193 (CID 1261822) is a potent, selective GPR55 antagonist with IC50 of 221 nM, shows >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively.

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25 mg	￥2880	In stock
50 mg	￥4580	In stock
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生物&药学活性

ML193 (CID 1261822) is a potent, selective GPR55 antagonist with IC50 of 221 nM, shows >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively.
ML193 reduces neuronal differentiation in vitro, increases anxiety-like behaviors while causing locomotor impairment by i.c.v. injection at the doses of 0.1 and 1 μg/rat.

物理化学性质&存储条件

分子量	527.59
分子式	C28H25N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide

参考文献

1. Kotsikorou E, et al. Biochemistry. 2013 Dec 31;52(52):9456-69.

2. Munawar N, et al. Front Pharmacol. 2017 Mar 20;8:136.

3. Drzazga A, et al. Biochem Biophys Res Commun. 2017 Jul 22;489(2):242-247.

4. Hill JD, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14387.

ML193 (ML 193;ML-193;CID 1261822)

生物&药学活性

物理化学性质&存储条件

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ML193 (ML 193;ML-193;CID 1261822)

生物&药学活性

物理化学性质&存储条件

参考文献

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