ML188 | 3CLpro inhibitor | Probechem Biochemicals

Chemical Structure : ML188

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ML188 (ML 188, Jun8-48-1)

货号: PC-72195Not For Human Use, Lab Use Only.

ML188 (ML 188, Jun8-48-1) is a potent, selective, noncovalent small molecule inhibitor of the SARS-CoV 3CL protease (3CLpro) with IC50 of 1.5 uM, inactive against PLpro.

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生物&药学活性

ML188 (ML 188, Jun8-48-1) is a potent, selective, noncovalent small molecule inhibitor of the SARS-CoV 3CL protease (3CLpro) with IC50 of 1.5 uM, inactive against PLpro.
ML188 displays antiviral activity against SARS-CoV Urbani infected Vero E6 cells with EC50 of 12.9 uM.
ML188 exhibits no significant activity against 68 discrete GPCRs, ion channels and transporters, has excellent aqueous solubility up to 95 ug/mL or 219 uM.

物理化学性质&存储条件

分子量	433.552
分子式	C26H31N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
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Solubility
Chemical Name/SMILES

参考文献

1. Jacobs J, et al. J Med Chem. 2013 Jan 24;56(2):534-46.

2. Turlington M, et al. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6172-7.

3. Lockbaum GJ, et al. Viruses. 2021 Jan 25;13(2):174. doi: 10.3390/v13020174.

ML188 (ML 188, Jun8-48-1)

生物&药学活性

物理化学性质&存储条件

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ML188 (ML 188, Jun8-48-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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