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首页-小分子抑制剂&激动剂-Others-Other Targets-ML180
ML180

Chemical Structure : ML180

CAS No.: 863588-32-3

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ML180 (ML 180, SR1848)

货号: PC-38445Not For Human Use, Lab Use Only.

ML180 (SR1848) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 3.7 uM in reporter assays, displays no activity against SF1 (NR5A1).

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5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML180 (SR1848) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 3.7 uM in reporter assays, displays no activity against SF1 (NR5A1).
ML180 shows 60% maximum repression of LRH1 transcription and is potent in a variety of breast cancer cell lines in MTT assays.
ML180 decreased cell-cycle-related gene transcripts and downstream targets in vitro.

物理化学性质&存储条件

分子量 388.89
分子式 C20H25ClN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione

参考文献

1. Busby S, et al. National Center for Biotechnology Information (US); 2010-.

2. Meinsohn MC, et al. J Endocr Soc. 2017 Dec 1;2(1):24-41.

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