ML179 (SR1309) | LRH1 (NR5A2) inhibitor | Probechem Biochemicals

Chemical Structure : ML179

CAS No.: 1883548-87-5

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ML179 (ML 179, SR1309)

货号: PC-38444Not For Human Use, Lab Use Only.

ML179 (SR1309) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 320 nM in reporter assays, displays no activity against SF1 (NR5A1).

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

ML179 (SR1309) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 320 nM in reporter assays, displays no activity against SF1 (NR5A1).
ML179 is potent in a variety of breast cancer cell lines in MTT assays.
ML179 significantly reduced mRNA expression of FXR targets ATP binding cassette subfamily C member 2/multidrug resistance associated protein 2 (ABCC2/MRP2), nuclear receptor subfamily 0, groupB, member 2/small heterodimer partner (NR0B2/SHP), and ATP binding cassette subfamily B member 11/bile salt export pump (ABCB11/BSEP) in HepG2 cells and primary mouse hepatocytes.

物理化学性质&存储条件

分子量	422.44
分子式	C21H25F3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-2,4(1H,3H)-pyrimidinedione

参考文献

1. Busby S, et al. National Center for Biotechnology Information (US); 2010-.

2. Swati Ghosh, et al. Hepatology. 2021 Dec;74(6):3284-3300.

ML179 (ML 179, SR1309)

生物&药学活性

物理化学性质&存储条件

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ML179 (ML 179, SR1309)

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物理化学性质&存储条件

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