ML 171 |CAS:6631-94-3 Probechem Biochemicals

Chemical Structure : ML 171

CAS No.: 6631-94-3

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ML 171 (2-Acetylphenothiazine; 2-APT; ML171)

货号: PC-60723Not For Human Use, Lab Use Only.

ML 171 is a potent, specific, cell-active NADPH oxidase1 (Nox1) inhibitor that strongly blocks ROS generation in HT29 cells with IC50 of 0.129 uM.

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生物&药学活性

ML 171 is a potent, specific, cell-active NADPH oxidase1 (Nox1) inhibitor that strongly blocks ROS generation in HT29 cells with IC50 of 0.129 uM.
ML 171 shows only marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms.
ML 171 also blocks the ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells.

物理化学性质&存储条件

分子量	241.31
分子式	C14H11NOS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Acetylphenothiazine

参考文献

1. Gianni D, et al. ACS Chem Biol. 2010 Oct 15;5(10):981-93.

2. Martínez-Revelles S, et al. Antioxid Redox Signal. 2013 Jan 1;18(1):51-65.

3. Walsh TG, et al. Redox Biol. 2014 Jan 13;2:178-86.

4. Gianni D, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

ML 171 (2-Acetylphenothiazine; 2-APT; ML171)

生物&药学活性

物理化学性质&存储条件

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ML 171 (2-Acetylphenothiazine; 2-APT; ML171)

生物&药学活性

物理化学性质&存储条件

参考文献

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