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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Integrin-ML165
ML165

Chemical Structure : ML165

CAS No.: 1355454-05-5

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ML165 (RUC-2, ML 165)

货号: PC-61134Not For Human Use, Lab Use Only.

ML165 (RUC-2) is a high-affinity, selective platelet integrin αIIbβ3 receptor antagonist with IC50 of 96 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ML165 (RUC-2) is a high-affinity, selective platelet integrin αIIbβ3 receptor antagonist with IC50 of 96 nM.
    ML165 (RUC-2) specifically inhibits ligand binding by a novel mechanism, leading to loss of the MIDAS metal ion while producing only minor changes in the conformation of β3.

    物理化学性质&存储条件

    分子量 385.446
    分子式 C17H19N7O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-amino-N-(3-(5-oxo-7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)phenyl)acetamide

    参考文献

    1. Zhu J, et al. Sci Transl Med. 2012 Mar 14;4(125):125ra32.

    2. Jiang JK, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1148-53.

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